Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Base Information

Chemical Name:Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester
CAS No.:155433-66-2
Molecular Formula:C₂₉H₄₀O₈
Molecular Weight:516.632
Hs Code.:

Synonyms:Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Suppliers and Price of Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

There total 24 articles about Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: Acetic acid (1R,2S,5S)-1-[(1R,2S)-3-acetoxy-1-methyl-2-(tetrahydro-pyran-2-yloxy)-propyl]-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

: 155433-66-2
Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; for 36h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81547-7

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 155433-66-2
Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 13 steps

2: 92 percent / diisobutyl aluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

3: 90 percent / (-)-diisopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, MS 4 Angstroem / CH₂Cl₂; toluene / 11 h / -20 °C

4: 91 percent / Red-al / toluene; tetrahydrofuran / 10.2 h / 0 °C

5: 93 percent / triethylamine, 4-DMAP / CH₂Cl₂ / 4 h / Ambient temperature

6: sodium hydride / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature

7: sodium bromide / dimethylformamide / 48 h / Ambient temperature

8: Mg / tetrahydrofuran / 1 h / Irradiation

9: CuI / tetrahydrofuran

10: 93 percent / 4-dimethylaminopyridine / tetrahydrofuran / 12 h / Ambient temperature

11: 62 percent / lithium aluminum hydride / tetrahydrofuran / 14 h / Ambient temperature

12: 91 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 12 h / Ambient temperature

13: 86 percent / PPTS / methanol / 36 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; lithium aluminium tetrahydride; (-)-diisopropyl tartrate; MS 4 Angstroem; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; magnesium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium bromide; copper(l) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)81547-7

Reference yield:

: 14755-02-3,588-30-7
3-hydroxy-trans-cinnamic acid

: 155433-66-2
Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 13 steps

2: 92 percent / diisobutyl aluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

3: 90 percent / (-)-diisopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, MS 4 Angstroem / CH₂Cl₂; toluene / 11 h / -20 °C

4: 91 percent / Red-al / toluene; tetrahydrofuran / 10.2 h / 0 °C

5: 93 percent / triethylamine, 4-DMAP / CH₂Cl₂ / 4 h / Ambient temperature

6: sodium hydride / tetrahydrofuran; dimethylformamide / 5 h / Ambient temperature

7: sodium bromide / dimethylformamide / 48 h / Ambient temperature

8: Mg / tetrahydrofuran / 1 h / Irradiation

9: CuI / tetrahydrofuran

10: 93 percent / 4-dimethylaminopyridine / tetrahydrofuran / 12 h / Ambient temperature

11: 62 percent / lithium aluminum hydride / tetrahydrofuran / 14 h / Ambient temperature

12: 91 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 12 h / Ambient temperature

13: 86 percent / PPTS / methanol / 36 h / Ambient temperature

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; lithium aluminium tetrahydride; (-)-diisopropyl tartrate; MS 4 Angstroem; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; magnesium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium bromide; copper(l) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)81547-7