2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: 2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
• CAS No.: 51928-84-8
• Molecular Formula: C₁₃H₁₅IO₄
• Molecular Weight: 362.164
• Mol file: 51928-84-8.mol

Synonyms:2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property of 2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

There total 1 articles about 2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Iodobenzoic acid (88-67-5) + (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → 2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (51928-84-8)

Guidance literature:

With dicyclohexyl-carbodiimide; dmap; In dichloromethane; at 25 ℃; for 20h;

DOI:10.1016/S0040-4039(00)96681-4

Reference yield: 90.0%

2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (51928-84-8) → glyceryl-o-iodobenzoate (51928-81-5)

Guidance literature:

With sulfuric acid; In ethanol; water; 1) 25 deg C, 20 h; 2) reflux, 1 h;

DOI:10.1016/S0040-4039(00)96681-4

Reference yield:

2-Iodo-benzoic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (51928-84-8) → 2-Iodo-benzoic acid 2,3-bis-octanoyloxy-propyl ester (115479-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 2N H₂SO₄ / ethanol; H₂O / 1) 25 deg C, 20 h; 2) reflux, 1 h

2: 89 percent / dicyclohexyl carbodiimide / 4-dimethylaminopyridine / CH₂Cl₂ / 36 h / 25 °C

With sulfuric acid; dicyclohexyl-carbodiimide; dmap; In ethanol; dichloromethane; water;

DOI:10.1016/S0040-4039(00)96681-4

upstream raw materials:

2-Iodobenzoic acid

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

Downstream raw materials:

glyceryl-o-iodobenzoate

2-Iodo-benzoic acid 2,3-bis-octanoyloxy-propyl ester

2-Iodo-benzoic acid 2,3-bis-hexadecanoyloxy-propyl ester