Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI)

Base Information

Chemical Name:Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI)
CAS No.:163659-47-0
Molecular Formula:C28H38 N4 O6
Molecular Weight:526.62452
Hs Code.:
Mol file:163659-47-0.mol

Synonyms:Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI)

Chemical Property:

PSA：148.85000
LogP:3.12810

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI)

There total 4 articles about Glycinamide, N-[1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-methoxy-2-oxoethyl]-L-alanyl-L-phenylalanyl-, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 55264-42-1
glycine amide hydrobromide

: 163659-45-8,163659-46-9
(S)-2-{(S)-2-[(S)-2-(4-tert-Butoxy-phenyl)-1-methoxycarbonyl-ethylamino]-propionylamino}-3-phenyl-propionic acid

: 163659-47-0,163659-48-1
(S)-3-(4-tert-Butoxy-phenyl)-2-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylamino}-propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 16h;
DOI:10.1039/c39930000304

Reference yield:

: 962-39-0
L-Phenylalanine benzyl ester

: 163659-47-0,163659-48-1
(S)-3-(4-tert-Butoxy-phenyl)-2-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: 75 percent / Ag₂O / toluene / 3 h / Ambient temperature

3: 95 percent / H₂ / Pd/C / ethanol / 1 h / Ambient temperature

4: 71 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC), Et₃N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h / -5 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; silver(l) oxide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c39930000304

Reference yield:

: 148080-99-3,163659-44-7
(S)-2-{(S)-2-[(S)-2-(4-tert-Butoxy-phenyl)-1-methoxycarbonyl-ethylamino]-propionylamino}-3-phenyl-propionic acid benzyl ester

: 163659-47-0,163659-48-1
(S)-3-(4-tert-Butoxy-phenyl)-2-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-ethylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd/C / ethanol / 1 h / Ambient temperature

2: 71 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC), Et₃N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h / -5 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c39930000304