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Technology Process of 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one

3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one

Base Information
  • Chemical Name:3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one
  • CAS No.:163655-37-6
  • Molecular Formula:C21H18 N2 O
  • Molecular Weight:314.38
  • Hs Code.:2933790090
  • European Community (EC) Number:634-088-2
  • Mol file:163655-37-6.mol
3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one

Synonyms:MAZ51;163655-37-6;(E)-3-((4-(dimethylamino)naphthalen-1-yl)methylene)indolin-2-one;3-((4-(dimethylamino)naphthalen-1-yl)methylene)indolin-2-one;EX-A1914;AKOS040759426;AC-36245;BS-47780;HY-116624;CS-0066097;S0765;E73474;J-010073

Suppliers and Price of 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • MAZ51
  • 50mg
  • $ 685.00
  • TRC
  • MAZ51
  • 100mg
  • $ 1260.00
  • Medical Isotopes, Inc.
  • MAZ51
  • 25 mg
  • $ 720.00
  • DC Chemicals
  • MAZ51 >98%
  • 250 mg
  • $ 900.00
  • DC Chemicals
  • MAZ51 >98%
  • 100 mg
  • $ 550.00
  • ChemScene
  • MAZ51 98.21%
  • 50mg
  • $ 520.00
  • ChemScene
  • MAZ51 98.21%
  • 100mg
  • $ 880.00
  • ChemScene
  • MAZ51 98.21%
  • 25mg
  • $ 310.00
  • ChemScene
  • MAZ51 98.21%
  • 10mg
  • $ 155.00
  • Cayman Chemical
  • MAZ51 ≥95%
  • 5mg
  • $ 98.00
Total 12 raw suppliers
Chemical Property of 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one
Chemical Property:
  • Refractive Index:1.729 
  • PSA：32.34000 
  • LogP:4.53650 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: 11 mg/mL 
  • XLogP3:4.3
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:2
  • Exact Mass:314.141913202
  • Heavy Atom Count:24
  • Complexity:512
Purity/Quality:

99%, *data from raw suppliers

MAZ51 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xn,N 
  • Statements: 22-37/38-41-51/53 
  • Safety Statements: 26-39-61 
MSDS Files:

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O
  • Isomeric SMILES:CN(C)C1=CC=C(C2=CC=CC=C21)/C=C/3\C4=CC=CC=C4NC3=O
  • Description The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2. It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ. By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.
  • Uses MAZ51 is an indolinone compound that selectively antagonizes the activation of VEGFR-3 by VEGF-C without blocking VEGF-C mediated stumulation of VEGFR-2. This reduces proliferation and induces apoptosis in various cancer cells and suppresses tumor growth.
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