tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate
CAS No.:1380336-92-4
Molecular Formula:C₁₉H₂₇N₅O₄
Molecular Weight:389.454
Hs Code.:

Synonyms:tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

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Chemical Property of tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

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Technology Process of tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

There total 3 articles about tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 937-31-5
(4-Nitrophenyl)acetylene

: 1380336-93-5
tert-butyl (R)-4-((S)-sec-butyl)-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide

: 1380336-92-4
tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

Guidance literature:: With sodium azide; copper; copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 120 ℃; for 0.416667h; under 517.162 - 3102.97 Torr; regioselective reaction; Sealed tube; Microwave irradiation;
DOI:10.1039/c2cc32392c

Reference yield:

: C₁₁H₂₁NO₄S

: 1380336-92-4
tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0 °C

2: sodium azide; copper; copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 0.42 h / 120 °C / 517.16 - 3102.97 Torr / Sealed tube; Microwave irradiation

With ruthenium trichloride; sodium periodate; sodium azide; copper; copper(II) sulfate; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc32392c

Reference yield:

: 106946-74-1,141321-50-8,141321-53-1,141321-52-0,545433-88-3
Boc-D-allo-isoleucinol

: 1380336-92-4
tert-butyl ((2R,3S)-3-methyl-1-(4-(4-nitrophenyl)-1H-1,2,3-triazol-1-yl)pentan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetonitrile / 0.92 h / -40 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0 °C

3.1: sodium azide; copper; copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 0.42 h / 120 °C / 517.16 - 3102.97 Torr / Sealed tube; Microwave irradiation

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium azide; copper; copper(II) sulfate; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c2cc32392c