(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Base Information

Chemical Name:(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane
CAS No.:157117-32-3
Molecular Formula:C₃₈H₆₆O₇Si
Molecular Weight:663.023
Hs Code.:

(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Synonyms:(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Suppliers and Price of (5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

There total 3 articles about (5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: (5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-5-hydroxy-6,8,10-trimethyl-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

: 157117-32-3
(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Guidance literature:: With trifluorormethanesulfonic acid; In diethyl ether; at 20 ℃; for 0.5h;
DOI:10.1016/0040-4020(95)00548-M

Reference yield:

: 142144-24-9
(2S,3S,4S,5S,6S)-2,4,6-trimethyl-8-((2S,4R,6S)-2-methyl-4-methoxytetrahydropyran-6-yl)-3,5-di-tert-butylsilylenedioxyoctanal

: 157117-32-3
(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / TiCl₄ / CH₂Cl₂ / 0.5 h / -90 °C

2: 1.) O₃, 2.) TfOH / 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) Et₂O, 20 deg C, 1 h

With trifluorormethanesulfonic acid; titanium tetrachloride; ozone; In dichloromethane;
DOI:10.1021/ja00085a050

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 157117-31-2
(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-5-hydroxy-3-methylene-6,8,10-trimethyl-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-dodecane

: 157117-32-3
(5R,6S,7S,8S,9S,10S)-7,9-(di-tert-butylsilylenedioxy)-6,8,10-trimethyl-5-(para-methoxybenzyloxy)-12-((2S',4R',6S')-2-methyl-4-methoxytetrahydropyran-6-yl)-3-oxododecane

Guidance literature:: With trifluorormethanesulfonic acid; ozone; Yield given. Multistep reaction; 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) Et₂O, 20 deg C, 1 h;
DOI:10.1021/ja00085a050