(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Base Information

Chemical Name:(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid
CAS No.:170902-38-2
Molecular Formula:C₂₆H₄₀N₂O₄
Molecular Weight:444.615
Hs Code.:

Synonyms:(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Suppliers and Price of (2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

There total 6 articles about (2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 170902-38-2
(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / imidazole / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 1.) LDA / 1.) THF, hexane, 30 min, 2.) THF, hexane, 3 h

3: 97 percent / 49percent aq. HF / acetonitrile / 18 h / Ambient temperature

4: Et₃N / CH₂Cl₂

5: 35 percent / K₂CO₃ / xylene / 140 °C

6: 1M LiOH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

With 1H-imidazole; lithium hydroxide; hydrogen fluoride; potassium carbonate; triethylamine; lithium diisopropyl amide; In 1,2-dimethoxyethane; dichloromethane; acetonitrile; xylene;
DOI:10.1021/jm00047a001

Reference yield:

: 150323-18-5
(3S,4aS,8aS)-2-((2S,4R)-4-Benzyl-5-oxo-tetrahydro-furan-2-ylmethyl)-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

: 170902-38-2
(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; for 3h; Ambient temperature;
DOI:10.1021/jm00047a001

Reference yield:

: 62396-80-9
(5S)-(5-tert-butyldimethylsilyloxymethyl)furan-2(5H)-one

: 170902-38-2
(2R,4S)-2-Benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, hexane, 30 min, 2.) THF, hexane, 3 h

2: 97 percent / 49percent aq. HF / acetonitrile / 18 h / Ambient temperature

3: Et₃N / CH₂Cl₂

4: 35 percent / K₂CO₃ / xylene / 140 °C

5: 1M LiOH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

With lithium hydroxide; hydrogen fluoride; potassium carbonate; triethylamine; lithium diisopropyl amide; In 1,2-dimethoxyethane; dichloromethane; acetonitrile; xylene;
DOI:10.1021/jm00047a001