[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester
CAS No.:167831-96-1
Molecular Formula:C₄₀H₃₅NO₆
Molecular Weight:625.721
Hs Code.:

Synonyms:[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

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Chemical Property of [4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

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Technology Process of [4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

There total 1 articles about [4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 158980-61-1
1,1-dimethylethyl 3,5-bis(benzyloxy)-4-<6-(benzyloxy)-2-formylbenzoyl>benzoate

: 167831-96-1
[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

Guidance literature:: With hydroxylamine hydrochloride; In N,N-dimethyl-formamide; at 50 - 55 ℃; for 16h;
DOI:10.1021/jm020018f

Reference yield:

: 167831-96-1
[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

: trans-2-[4-[6-hydroxy-2-(3-methyltetrazolyl)benzoyl]-3,5-dihydroxybenzoyloxy]-1-(4-hydroxybenzamido)cylopentane

Guidance literature:: Multi-step reaction with 5 steps

1.1: TFA

2.1: (COCl)2

3.1: DIEA / CH₂Cl₂

4.1: 39 percent / n-Bu₂SnO; TMSN₃ / toluene / 48 h / 80 °C

5.1: Na₂CO₃ / 20percent Pd(OH)2/C / acetone; dimethylformamide / 1 h / 20 °C / 760.05 Torr

5.2: 35 percent / H₂ / 20percent Pd(OH)2/C / tetrahydrofuran; ethanol / 15.5 h / 760.05 Torr

With oxalyl dichloride; trimethylsilylazide; di(n-butyl)tin oxide; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20percent Pd(OH)2/C; In dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm020018f

Reference yield:

: 167831-96-1
[4-(2-benzyloxy-6-nitrilobenzoyl)-3,5-dibenzyloxy]benzoic acid 1,1-dimethylethyl ester

: trans-2-[4-(6-hydroxy-2-tetrazolylbenzoyl)-3,5-dihydroxybenzoyloxy]-1-(4-hydroxybenzamido)cylopentane

Guidance literature:: Multi-step reaction with 5 steps

1: TFA

2: (COCl)2

3: DIEA / CH₂Cl₂

4: 39 percent / n-Bu₂SnO; TMSN₃ / toluene / 48 h / 80 °C

5: 67 percent / H₂ / 20percent Pd(OH)2/C / tetrahydrofuran; ethanol / 15 h / 760.05 Torr

With oxalyl dichloride; trimethylsilylazide; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20percent Pd(OH)2/C; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jm020018f