(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

Base Information

Chemical Name:(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline
CAS No.:1106986-59-7
Molecular Formula:C₂₁H₂₉NO₂
Molecular Weight:327.467
Hs Code.:

Synonyms:(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

Suppliers and Price of (3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

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Technology Process of (3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

There total 6 articles about (3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1106986-30-4
(3R,7aS,11aS)-8-butyl-5-oxo-3-phenyl-2,3,5,6,7,7a,10,11-octahydrooxazolo[2,3-j]quinoline

: 1106986-59-7
(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jo802587h

Reference yield:

: (3R,7aS,8R,11aS)-8-butyl-5,10-dioxo-3-phenylperhydrooxazolo[2,3-j]quinoline

: 1106986-59-7
(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

Guidance literature:: (3R,7aS,8R,11aS)-8-butyl-5,10-dioxo-3-phenylperhydrooxazolo[2,3-j]quinoline; With 1.3-propanedithiol; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 16h;

In ethanol; for 23h; Reflux;
DOI:10.1021/acs.joc.8b00983

Reference yield:

: (3R,7aS,10R,11aS)-10-hydroxy-5-oxo-3-phenyl-2,3,5,6,7,7a,10,11-octahydrooxazolo[2,3-j]quinoline

: 1106986-59-7
(3R,7aS,8R,11aS)-8-butyl-5-oxo-3-phenylperhydrooxazolo-[2,3-j]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 20 °C

2.1: copper(l) iodide / dichloromethane; hexane; diethyl ether / 3.5 h / -78 - -30 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate; 1.3-propanedithiol / dichloromethane / 16 h / 20 °C

3.2: Ni-Raney / 23 h / Reflux

With 1.3-propanedithiol; copper(l) iodide; boron trifluoride diethyl etherate; Dess-Martin periodane; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/acs.joc.8b00983