(R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione

Base Information

• Chemical Name: (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione
• CAS No.: 1619261-42-5
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 1619261-42-5.mol

Synonyms:(R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione

Chemical Property of (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione

There total 5 articles about (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

phthalic anhydride (85-44-9) + (R)-3-amino-4-(3-methoxyphenyl)butan-1-ol hydrochloride (1619261-39-0) → (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione (1619261-42-5)

Guidance literature:

With triethylamine; In toluene; at 100 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tet.2014.06.008

Reference yield:

(R)-3-(tert-butoxycarbonylamino)-4-(3-methoxyphenyl)butyl 4-methylbenzenesulfonate (1619261-25-4) → (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione (1619261-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 29 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / water; methanol / 2 h / 70 °C / Inert atmosphere

2.2: 0.08 h / 20 °C / Inert atmosphere

3.1: triethylamine / toluene / 20 h / 100 °C / Inert atmosphere

With triethylamine; potassium hydroxide; lithium hydroxide; In methanol; water; dimethyl sulfoxide; toluene;

DOI:10.1016/j.tet.2014.06.008

Reference yield:

(R)-4-(3-methoxybenzyl)-1,3-oxazinan-2-one (1619261-36-7) → (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione (1619261-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / water; methanol / 2 h / 70 °C / Inert atmosphere

1.2: 0.08 h / 20 °C / Inert atmosphere

2.1: triethylamine / toluene / 20 h / 100 °C / Inert atmosphere

With triethylamine; lithium hydroxide; In methanol; water; toluene;

DOI:10.1016/j.tet.2014.06.008

upstream raw materials:

(R)-4-(3-methoxybenzyl)-1,3-oxazinan-2-one

(R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate

phthalic anhydride

(R)-3-amino-4-(3-methoxyphenyl)butan-1-ol hydrochloride