(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Base Information

Chemical Name:(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester
CAS No.:172974-08-2
Molecular Formula:C₃₀H₃₁Cl₃N₂O₆
Molecular Weight:621.945
Hs Code.:

Synonyms:(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

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Chemical Property of (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

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Technology Process of (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

There total 6 articles about (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 2791-84-6,227205-81-4
L-glutamic acid dibenzyl ester 4-toluenesulfonate

: 156079-41-3
Carbonic acid 4-[bis-(2-chloro-ethyl)-amino]-2-chloro-phenyl ester 4-nitro-phenyl ester

: 172974-08-2
(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Guidance literature:: With triethylamine; In chloroform; at 50 ℃; for 5h;
DOI:10.1021/jm00026a013

Reference yield:

: 3964-52-1
2-chloro 4-aminophenol

: 172974-08-2
(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / aq. AcOH / 48 h / Ambient temperature

2: 43 percent / KOH / ethanol / 2 h / Heating

3: 51 percent / CH₃SO₂Cl, pyridine / 0.25 h / 70 °C

4: 60 percent / H₂, HCl / 30percent Pd/C / ethanol; diethyl ether

5: 48 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

6: 39 percent / Et₃N / CHCl₃ / 5 h / 50 °C

With pyridine; hydrogenchloride; potassium hydroxide; hydrogen; acetic acid; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; chloroform;
DOI:10.1021/jm00026a013

Reference yield:

: 156079-12-8
4-[bis-(2-hydroxy-ethyl)-amino]-2-chloro-phenol

: 172974-08-2
(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2-chloro-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / KOH / ethanol / 2 h / Heating

2: 51 percent / CH₃SO₂Cl, pyridine / 0.25 h / 70 °C

3: 60 percent / H₂, HCl / 30percent Pd/C / ethanol; diethyl ether

4: 48 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

5: 39 percent / Et₃N / CHCl₃ / 5 h / 50 °C

With pyridine; hydrogenchloride; potassium hydroxide; hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; chloroform;
DOI:10.1021/jm00026a013