(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283145-89-0
Molecular Formula:C₂₀H₂₀F₂N₂
Molecular Weight:326.389
Hs Code.:

Synonyms:(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of (R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Chemical Property:

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Technology Process of (R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

There total 7 articles about (R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 312693-19-9
(2-methylbenzyl)zinc(II)chloride

: 1283145-88-9
(R)-2-(1-(4-bromophenyl)-4,4-difluoropyrrolidin-2-yl)acetonitrile

: 1283145-89-0
(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1283145-89-0
(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 15 h / 90 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dimethyl sulfoxide / 15 h / 50 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 100 °C / Inert atmosphere

With triethylamine; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1283145-87-8
(S)-(1-(4-bromophenyl)-4,4-difluoropyrrolidin-2-yl)methanol

: 1283145-89-0
(R)-2-(4,4-difluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: dimethyl sulfoxide / 15 h / 50 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;