(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

Base Information

Chemical Name:(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate
CAS No.:1449786-53-1
Molecular Formula:C₂₉H₃₄N₄O₄
Molecular Weight:502.613
Hs Code.:

Synonyms:(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

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Chemical Property of (S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

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Technology Process of (S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

There total 5 articles about (S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449786-47-3
(S)-benzyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzamido)-3-methylbutanoate

: 1449786-53-1
(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 1449786-44-0
(S)-methyl 4-amino-3-(2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzoate

: 1449786-53-1
(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 36692-49-6
Methyl 3,4-diaminobenzoate

: 1449786-53-1
(S)-benzyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

2: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024