1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

Base Information

Chemical Name:1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate
CAS No.:84080-49-9
Molecular Formula:C₂₂H₃₂N₂O₇Si
Molecular Weight:464.591
Hs Code.:

Synonyms:1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

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Chemical Property of 1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

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Technology Process of 1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

There total 9 articles about 1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 84080-48-8
2-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>malonic acid

: 84080-49-9
1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

Guidance literature:: With sodium hydrogencarbonate; In ethanol; for 1h; Ambient temperature;
DOI:10.1002/hlca.19820650508

Reference yield:

: 84080-31-9
dibenzyl 2-amino-2-(hydroxy-methoxycarbonylmethyl)malonate

: 84080-49-9
1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

Guidance literature:: Multi-step reaction with 9 steps

1: 40 percent / imidazole / dimethylformamide / 4 h / 25 °C

2: benzene / 18 h / Heating; Dean-Stark strap

3: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

4: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

5: pyridine / CH₂Cl₂ / 2 h

6: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

7: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

8: 50 percent / H₂ / Pd/C / ethyl acetate / 3 h / 25 °C / 2327.2 Torr

9: 70 percent / 10percent NaHCO₃ / ethanol / 1 h / Ambient temperature

With pyridine; 1H-imidazole; Wilkinson's catalyst; dimethylsulfide; hydrogen sulfide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.19820650508

Reference yield:

: 84080-32-0
dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

: 84080-49-9
1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

Guidance literature:: Multi-step reaction with 8 steps

1: benzene / 18 h / Heating; Dean-Stark strap

2: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

3: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

4: pyridine / CH₂Cl₂ / 2 h

5: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

6: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

7: 50 percent / H₂ / Pd/C / ethyl acetate / 3 h / 25 °C / 2327.2 Torr

8: 70 percent / 10percent NaHCO₃ / ethanol / 1 h / Ambient temperature

With pyridine; Wilkinson's catalyst; dimethylsulfide; hydrogen sulfide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1002/hlca.19820650508