Technology Process of 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-(2-hydroxyethyl)-N-methylacetamide
There total 13 articles about 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-(2-hydroxyethyl)-N-methylacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen fluoride; water;
In
acetonitrile;
at 20 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 55 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.2: 2 h
3.1: thionyl chloride / 20 °C
4.1: dimethyl sulfoxide / 5 h / 70 °C
5.1: thionyl chloride / Cooling with ice
5.2: 16 h / 70 °C
6.1: sodium hydroxide; methanol / 5 h / 50 °C
6.2: pH 3
7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
8.1: water; hydrogen fluoride / acetonitrile / 5 h / 20 °C
With
methanol; lithium aluminium tetrahydride; thionyl chloride; hydrogen fluoride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 20 °C
2.1: dimethyl sulfoxide / 5 h / 70 °C
3.1: thionyl chloride / Cooling with ice
3.2: 16 h / 70 °C
4.1: sodium hydroxide; methanol / 5 h / 50 °C
4.2: pH 3
5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
6.1: water; hydrogen fluoride / acetonitrile / 5 h / 20 °C
With
methanol; thionyl chloride; hydrogen fluoride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
