6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl

Base Information

• Chemical Name: 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl
• CAS No.: 256387-77-6
• Molecular Formula: C₇₂H₈₄I₂O₁₈
• Molecular Weight: 1491.26
• Mol file: 256387-77-6.mol

Synonyms:6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl

Chemical Property of 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl

There total 8 articles about 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 4,4'''''-diiodo-[1,4';1',1'';4'',4''';1''',1'''';4'''',1''''']sexiphenyl-3,2',2'',2''',2'''',3'''''-hexaol (1032671-04-7) → 64,14-diiodo-63,52,43,32,23,13-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl (256387-77-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

DOI:10.1021/ol991210n

Reference yield:

4,4'-diiodo-3,3'-di(tert-butoxycarbonyl-methoxy)biphenyl (256387-73-2) + [3'-tert-butoxycarbonylmethoxy-4,4'-bis-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-3-yloxy]-acetic acid tert-butyl ester → 64,14-diiodo-63,52,43,32,23,13-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl (256387-77-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 24h;

DOI:10.1021/ol991210n

Reference yield:

o-dianisidine bisdiazotated zinc doublesalt (84633-94-3) → 64,14-diiodo-63,52,43,32,23,13-hexa(tert-butoxycarbonylmethoxy)-p-sexiphenyl (256387-77-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / KI / H₂O / 14 h / 0 °C

2: BBr₃ / CH₂Cl₂ / 14 h / -78 - 20 °C

3: 2.65 g / Cs₂CO₃ / dimethylformamide / 0.25 h / 60 °C

4: PdCl₂(dppf); triethylamine / acetonitrile / 80 °C

5: 20 mg / PdCl₂(dppf); Na₂CO₃ / toluene; ethanol; H₂O / 24 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; boron tribromide; sodium carbonate; caesium carbonate; triethylamine; potassium iodide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Iodination / 2: demethylation / 3: Etherification / 4: Condensation / 5: Condensation;

DOI:10.1021/ol991210n

upstream raw materials:

bromoacetic acid tert-butyl ester

4,4'''''-diiodo-[1,4';1',1'';4'',4''';1''',1'''';4'''',1''''']sexiphenyl-3,2',2'',2''',2'''',3'''''-hexaol

4,4'-diiodo-3,3'-di(tert-butoxycarbonyl-methoxy)biphenyl

fast blue B

Downstream raw materials:

8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(tert-butoxycarbonylmethoxy)-p-octiphenyl

1⁴,8⁴-bismethoxy-2²,3³,4²,5³,6²,7³-hexa(tert-butyloxycarbonylmethoxy)-p-octiphenyl

C₈₆H₉₈O₁₉S