(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Base Information

Chemical Name:(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
CAS No.:1260585-59-8
Molecular Formula:C₂₀H₂₂F₄N₄O₂
Molecular Weight:426.414
Hs Code.:

Synonyms:(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

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Chemical Property of (8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

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Technology Process of (8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

There total 5 articles about (8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60907-87-1
2-fluoro-α-methylbenzyl chloride

: 1260585-10-1
(8S)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

: 1260585-59-8
(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: (R,S)-8-chloro-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one

: 1260585-59-8
(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: Chiralpak AD / ethanol; n-heptane / Resolution of racemate

2: 1.5 h / 80 °C

3: caesium carbonate / acetonitrile / 2 h / 80 °C / Inert atmosphere

With caesium carbonate; In ethanol; n-heptane; acetonitrile;

Reference yield:

: (4R,4S)-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2-ylamine hydrochloride

: 1260585-59-8
(8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / 1.25 h / 100 °C

1.2: pH 5 - 6

2.1: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere

3.1: Chiralpak AD / ethanol; n-heptane / Resolution of racemate

4.1: 1.5 h / 80 °C

5.1: caesium carbonate / acetonitrile / 2 h / 80 °C / Inert atmosphere

With sodium methylate; caesium carbonate; trichlorophosphate; In ethanol; n-heptane; 1,2-dichloro-ethane; acetonitrile;