S-3-PHENYL-2-[N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL]INDOLE

Base Information

• Chemical Name: S-3-PHENYL-2-[N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL]INDOLE
• CAS No.: 163064-67-3
• Molecular Formula: C₂₀H₁₇F₃N₂O
• Molecular Weight: 358.363
• Mol file: 163064-67-3.mol

Synonyms:Pyrrolidine,2-(3-phenyl-1H-indol-2-yl)-1-(trifluoroacetyl)-, (S)-

Chemical Property of S-3-PHENYL-2-[N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL]INDOLE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

S-3-PHENYL-2-(N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL)INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-3-PHENYL-2-[N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL]INDOLE

There total 3 articles about S-3-PHENYL-2-[N-(TRIFLUOROACETYL)PYRROLIDIN-2-YL]INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C20H17F3N2O3 → (R)-(+)-3-phenyl-2-indole (163064-67-3)

Guidance literature:

With titanium(III) chloride; zinc; In 1,2-dimethoxyethane; for 2h; regioselective reaction; Inert atmosphere; Reflux;

DOI:10.15227/orgsyn.076.0142

Reference yield: 67.0%

1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid (2-benzoyl-phenyl)-amide → (S)-(-)-3-Phenyl-2-indole (163064-67-3) + (R)-(+)-3-phenyl-2-indole (163064-67-3)

Guidance literature:

With chloro-trimethyl-silane; titanium(III) chloride; zinc; In acetonitrile; for 0.5h; Title compound not separated from byproducts; Heating;

Reference yield: 67.0%

1-(2,2,2-Trifluoro-acetyl)-pyrrolidine-2-carboxylic acid (2-benzoyl-phenyl)-amide → (S)-(-)-3-Phenyl-2-indole (163064-67-3) + (R)-(+)-3-phenyl-2-indole (163064-67-3)

Guidance literature:

With chloro-trimethyl-silane; titanium(III) chloride; zinc; In acetonitrile; for 0.5h; Title compound not separated from byproducts; Heating;

Refernces

• 1、 Fürstner, Alois,Hupperts, Achim. "Carbonyl coupling reactions catalytic in titanium and the use of commercial titanium powder for organic synthesis". . p. 4468 - 4475. Retrieved 2007/10/02.