N-BOC-L-PHENYLGLYCINAL

Base Information

• Chemical Name: N-BOC-L-PHENYLGLYCINAL
• CAS No.: 163061-19-6
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Hs Code.: 2924299090
• Mol file: 163061-19-6.mol

Synonyms:Carbamicacid, (2-oxo-1-phenylethyl)-, 1,1-dimethylethyl ester, (S)-;Carbamic acid,[(1S)-2-oxo-1-phenylethyl]-, 1,1-dimethylethyl ester (9CI);N-(tert-Butoxylcarbonyl)-L-phenylglycinal;tert-butyl [(1S)-2-oxo-1-phenylethyl]carbamate;carbamic acid, N-[(1S)-2-oxo-1-phenylethyl]-, 1,1-dimethylethyl ester;tert-butyl [(1S)-2-oxo-1-phenylethyl]carbamate;

Chemical Property of N-BOC-L-PHENYLGLYCINAL

Chemical Property:

• Boiling Point: 356.67 °C at 760 mmHg
• Flash Point: 169.508 °C
• PSA: 55.40000
• Density: 1.093 g/cm³
• LogP: 2.84220

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl(S)-formyl(phenyl)methylcarbamate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-L-PHENYLGLYCINAL

There total 18 articles about N-BOC-L-PHENYLGLYCINAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (1S)-2,3-dihydroxy-1-phenylpropylcarbamate (757195-52-1) → (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde (163061-19-6)

Guidance literature:

With sodium periodate; In diethyl ether; water; at 20 ℃; for 1h;

DOI:10.1021/jo049517+

Reference yield: 88.0%

tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate (117049-14-6) → (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde (163061-19-6)

Guidance literature:

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at -10 ℃;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield: 87.0%

N-tert-butoxycarbonyl-L-phenylglycine methyl ester (143978-88-5) → (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde (163061-19-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃;

DOI:10.1039/c3cc47867j

upstream raw materials:

tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

N-tert-butoxycarbonyl-L-phenylglycine methyl ester

tert-butyl (S)-{2-[methoxy(methyl)amino]-2-oxo-1-phenylethyl}carbamate

(4S,5R)-5-benzyloxy-3-tert-butoxycarbonyl-4-phenyl-2-oxazolidinone

Downstream raw materials:

(2E,4R)-4-(t-butoxycarbonylamino)-4-phenylbutenbutenoic acid methyl ester

(E)-ethyl 4-(tert-butoxycarbonylamino)-4-phenylbut-2-enoate

Refernces

• 1、 Kumar, Mothukuri Ganesh,Thombare, Varsha J.,Bhaisare, Rupal D.,Adak, Anindita,Gopi, Hosahudya N.. "Synthesis of tetrasubstituted symmetrical pyrazines from β-keto γ-amino esters: A mild strategy for self-dimerization of peptides". . p. 135 - 141. Retrieved 2015/02/02.
• 2、 Jones, Raymond C. F.,Bullous, James P.,Law, Carole C. M.,Elsegood, Mark R. J.. "New routes towards reutericyclin analogues". . p. 1588 - 1590. Retrieved 2014/02/14.