3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

Base Information

Chemical Name:3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile
CAS No.:297179-06-7
Molecular Formula:C₂₆H₂₉NO₂
Molecular Weight:387.522
Hs Code.:

3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5<sup>(10)</sup>-triene-16-nitrile

Synonyms:3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

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Chemical Property of 3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

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Technology Process of 3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

There total 2 articles about 3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3-(benzyloxy)-16-(hydroxyimino)-17α-methylestra-1,3,5(10)-trien-17β-ol

: 297179-06-7
3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

Guidance literature:: With pyridine; acetic anhydride; at 100 ℃; for 2h;
DOI:10.1135/cccc20050063

Reference yield:

: 262293-85-6
3-(benzyloxy)-16-(hydroxyimino)-estra-1,3,5⁽¹⁰⁾-trien-17-one

: 297179-06-7
3-(benzyloxy)-17-methyl-17-oxo-16,17-secoestra-1,3,5⁽¹⁰⁾-triene-16-nitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether

1.2: 70 percent / diethyl ether; tetrahydrofuran / 2 h / 20 °C

2.1: 81 percent / pyridine; Ac₂O / 2 h / 100 °C

With pyridine; acetic anhydride; magnesium; In diethyl ether; 2.1: Beckmann fragmentation;
DOI:10.1135/cccc20050063