4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

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Chemical Name:4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate
CAS No.:1254099-13-2
Molecular Formula:C₂F₃O₂*C₃₉H₅₁N₄O₆
Molecular Weight:784.873
Hs Code.:

4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

Synonyms:4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

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Chemical Property of 4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

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Technology Process of 4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

There total 3 articles about 4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

: C₃₅H₄₇N₂O₄⁽¹⁺⁾*I^(1-)

: 1254099-13-2
4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

Guidance literature:: C₃₅H₄₇N₂O₄⁽¹⁺⁾*I^(1-); With triphenylphosphin polymer bound; iodine; In dichloromethane; for 3h;

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield:

: 1-methylpiperidin-4-yl N-(5-{3-[(5-(hydroxypentyl)oxy)]propyl}-2-phenylphenyl)carbamate

: 1254099-13-2
4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 1 h / 20 °C

2.1: triphenylphosphin polymer bound / iodine / dichloromethane / 3 h

2.2: 3 h / 70 °C

With triphenylphosphin polymer bound; iodine; In dichloromethane; acetonitrile;

Reference yield:

: 1254103-15-5
1-methylpiperidin-4-yl N-{5-[(1E)-3-{[5-(benzyloxy)pentyl]oxy}-1-propen-1-yl]-2-phenylphenyl}carbamate

: 1254099-13-2
4-{[(5-{3-[(5-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pentyl)oxy]propyl}-2-phenylphenyl)carbamoyl]oxy}-1,1-dimethylpiperidin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium hydroxide, 20 wt% on carbon / methanol / 120 h / 20 - 90 °C

2.1: acetonitrile / 1 h / 20 °C

3.1: triphenylphosphin polymer bound / iodine / dichloromethane / 3 h

3.2: 3 h / 70 °C

With hydrogen; palladium hydroxide, 20 wt% on carbon; iodine; In methanol; dichloromethane; acetonitrile;