methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

Base Information

Chemical Name:methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate
CAS No.:126587-45-9
Molecular Formula:C₂₄H₄₁NO₅Si
Molecular Weight:451.679
Hs Code.:

Synonyms:methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

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Chemical Property of methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

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Technology Process of methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

There total 12 articles about methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81658-27-7
(S)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

: 126587-45-9
methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi, TMEDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1 h

2: 98 percent / Raney Ni (W-2) / acetone; H₂O / 12 h / 56 °C

3: 1M aq. NaOH / tetrahydrofuran / 12 h / 25 °C

4: methanol; diethyl ether

With sodium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Raney Ni (W-2); In tetrahydrofuran; methanol; diethyl ether; water; acetone;
DOI:10.1016/0040-4020(95)01058-0

Reference yield:

: 126587-43-7
(2S,3S)-3-benzyl-1-<(1,1-dimethylethoxy)carbonyl>-2-<<(1,1-dimethylethyl)dimethylsilyloxy>methyl>-5-pyrrolidone

: 126587-45-9
methyl (3S,4S)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1M aq. NaOH / tetrahydrofuran / 12 h / 25 °C

2: methanol; diethyl ether

With sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/0040-4020(95)01058-0

Reference yield:

: 126587-44-8
(2R,3R)-3-benzyl-1-<(1,1-dimethylethoxy)carbonyl>-2-<<(1,1-dimethylethyl)dimethylsilyloxy>methyl>-5-pyrrolidone

: 126587-45-9,126587-46-0
methyl (3R,4R)-3-benzyl-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-<<(1,1-dimethylethoxy)carbonyl>amino>pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1M aq. NaOH / tetrahydrofuran / 12 h / 25 °C

2: methanol; diethyl ether

With sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/0040-4020(95)01058-0