C₁₂H₁₀F₅NO₂

Base Information

• Chemical Name: C₁₂H₁₀F₅NO₂
• CAS No.: 1082985-08-7
• Molecular Formula: C₁₂H₁₀F₅NO₂
• Molecular Weight: 295.209
• Mol file: 1082985-08-7.mol

Synonyms:C₁₂H₁₀F₅NO₂

Chemical Property of C₁₂H₁₀F₅NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₂H₁₀F₅NO₂

There total 2 articles about C₁₂H₁₀F₅NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4,5,6-pentafluorophenol (771-61-9) + N-methyl-D-proline (475-11-6,58123-62-9,68078-09-1) → C12H10F5NO2 (1082985-08-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 23 ℃; for 17h;

DOI:10.1021/jm701321p

Reference yield:

D-Prolin (344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → C12H10F5NO2 (1082985-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / water; methanol

2: dicyclohexyl-carbodiimide / ethyl acetate

With palladium on activated charcoal; hydrogen; dicyclohexyl-carbodiimide; In methanol; water; ethyl acetate;

Reference yield: 61.0%

C12H10F5NO2 (1082985-08-7) + C34H48N4O6S → (S,E)-4-(2-((1R,3R)-1-acetoxy-3-((2S,3S)-N,3-dimethyl-2-((R)-1-methylpyrrolidine-2-carboxamido)pentanamido)-4-methylpentyl)-thiazole-4-carboxamido)-2-methyl-5-phenylpent-2-enoic acid 2,2,2-trifluoroacetate

Guidance literature:

C₁₂H₁₀F₅NO₂; C₃₄H₄₈N₄O₆S; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimedone; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01314

upstream raw materials:

2,3,4,5,6-pentafluorophenol

N-methyl-D-proline

D-Prolin

Refernces

• 1、 Colombo, Raffaele,Wang, Zhiyong,Han, Junyan,Balachandran, Raghavan,Daghestani, Hikmat N.,Camarco, Daniel P.,Vogt, Andreas,Day, Billy W.,Mendel, David,Wipf, Peter. "Total Synthesis and Biological Evaluation of Tubulysin Analogues". . p. 10302 - 10320. Retrieved 2016/11/17.