[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

Base Information

Chemical Name:[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester
CAS No.:166394-73-6
Molecular Formula:C₁₉H₂₀FN₂O₄P
Molecular Weight:390.351
Hs Code.:

Synonyms:[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

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Chemical Property of [4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

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Technology Process of [4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

There total 3 articles about [4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: [4-(2-Cyano-3-fluoro-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester

: 166394-73-6
[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In ethanol; for 24h;
DOI:10.1021/jm9506938

Reference yield:

: 28149-48-6
4-[(diethoxyphosphinyl)methyl]benzoic acid

: 166394-73-6
[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / CH₂Cl₂; dimethylformamide

2: pyridine

3: 50 percent / 30percent aq. H₂O₂, NaOH / ethanol / 24 h

With pyridine; sodium hydroxide; thionyl chloride; dihydrogen peroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9506938

Reference yield:

: 118578-91-9
4-[(diethoxyphosphoryl)-methyl]benzoyl chloride

: 166394-73-6
[4-(5-Fluoro-4-hydroxy-quinazolin-2-yl)-benzyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 50 percent / 30percent aq. H₂O₂, NaOH / ethanol / 24 h

With pyridine; sodium hydroxide; dihydrogen peroxide; In ethanol;
DOI:10.1021/jm9506938