1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

Base Information

Chemical Name:1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid
CAS No.:1026535-74-9
Molecular Formula:C₁₇H₁₂ClNO₃
Molecular Weight:313.74
Hs Code.:

Synonyms:1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

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Chemical Property of 1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

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Technology Process of 1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

There total 1 articles about 1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-Benzyl-1H-indole-2,7-dicarboxylic acid

: 1026535-74-9
1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00001a014

Reference yield:

: 1026535-74-9
1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

: 161488-60-4
2-(8-formyl-1-oxo-3-phenyl-1,2-dihydropyrido<3,4-b>indol-2-yl)-N-(2-hydroxy-3,3,3-trifluoro-1-isopropyl)propylacetamide

Guidance literature:: Multi-step reaction with 17 steps

1: triethylamine / CH₂Cl₂

2: conc. sulfuric acid / diethyl ether / 3 h

3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.)ethanol, H₂O, 2 h

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

6: nitromethane, aluminum chloride / benzene / 1 h

7: 48 percent / methanol; diethyl ether

8: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

9: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 1 h

10: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

11: triethylamine / CH₂Cl₂

12: 90 percent / conc. sulfuric acid / diethyl ether / 3 h

13: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

14: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

15: 73 percent / 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

16: 83 percent / nitromethane, aluminum chloride / benzene / 1 h

17: 32 percent / sodium hypophosphite monohydrate, pyridine, acetic acid / Raney nickel / H₂O / 2 h / 60 °C

With pyridine; dichloro-acetic acid; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium hypophosphite; aluminium trichloride; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014

Reference yield:

: 1026535-74-9
1-Benzyl-2-chlorocarbonyl-1H-indole-7-carboxylic acid

: 2-(8-Formyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]indol2-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 18 steps

1: triethylamine / CH₂Cl₂

2: conc. sulfuric acid / diethyl ether / 3 h

3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.)ethanol, H₂O, 2 h

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

6: nitromethane, aluminum chloride / benzene / 1 h

7: 48 percent / methanol; diethyl ether

8: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

9: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 1 h

10: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

11: triethylamine / CH₂Cl₂

12: 90 percent / conc. sulfuric acid / diethyl ether / 3 h

13: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

14: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

15: 73 percent / 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

16: 83 percent / nitromethane, aluminum chloride / benzene / 1 h

17: 32 percent / sodium hypophosphite monohydrate, pyridine, acetic acid / Raney nickel / H₂O / 2 h / 60 °C

18: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

With pyridine; dichloro-acetic acid; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium hypophosphite; aluminium trichloride; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014