5-Bromo-2-(bromomethyl)-1,3-difluorobenzene

Base Information

• Chemical Name: 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene
• CAS No.: 162744-60-7
• Molecular Formula: C7H4Br2F2
• Molecular Weight: 285.914
• Hs Code.: 2903999090
• European Community (EC) Number: 801-273-6
• DSSTox Substance ID: DTXSID40378356
• Wikidata: Q72454362
• Mol file: 162744-60-7.mol

Synonyms:5-Bromo-2-(bromomethyl)-1,3-difluorobenzene;162744-60-7;4-Bromo-2,6-difluorobenzyl bromide;Benzene, 5-bromo-2-(bromomethyl)-1,3-difluoro-;5-Bromo-2-bromomethyl-1,3-difluoro-benzene;MFCD03094462;5-bromo-2-(bromomethyl)-1,3-difluoro-benzene;SCHEMBL601770;DTXSID40378356;VSKMLLGUWKLTQV-UHFFFAOYSA-N;AKOS005145775;AM84556;AC-23895;AS-37142;SY106789;FT-0713510;EN300-1895850;A810414;J-516878;5-Bromo-2-(bromomethyl)-1,3-difluorobenzene, AldrichCPR;4-BROMO-2,6-DIFLUOROBENZYL BROMIDE

Chemical Property of 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene

Chemical Property:

• Vapor Pressure: 0.0498mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 243.532 °C at 760 mmHg
• Flash Point: 101.085 °C
• PSA: 0.00000
• Density: 1.992 g/cm³
• LogP: 3.62220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Lachrymatory
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 285.86273
• Heavy Atom Count: 11
• Complexity: 120

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2,6-difluorobenzyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1F)CBr)F)Br

Technology Process of 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene

There total 5 articles about 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(4-bromo-2,6-difluoro-phenyl)methanol (162744-59-4) → 5-bromo-2-(bromomethyl)-1,3-difluoro-benzene (162744-60-7)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 1.5h;

Reference yield: 79.0%

5-bromo-1,3-difluoro-2-methylbenzene → 5-bromo-2-(bromomethyl)-1,3-difluoro-benzene (162744-60-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Reflux;

Reference yield:

4-bromo-2,6-difluorobenzyl methanesulfonate (869361-54-6) → 5-bromo-2-(bromomethyl)-1,3-difluoro-benzene (162744-60-7)

Guidance literature:

With lithium bromide; In N,N-dimethyl-formamide; at 90 ℃; for 0.75h;

upstream raw materials:

(4-bromo-2,6-difluoro-phenyl)methanol

4-bromo-2,6-difluorobenzyl methanesulfonate

4-bromo-2,6-difluorobenzoic acid

4-bromo-2,6-difluorobenzaldehyde

Downstream raw materials:

4-(4-bromo-2,6-difluorobenzyl)morpholine

2-bromo-6-(4-bromo-2,6-difluorobenzyl)pyridine

2-(4-bromo-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

1-({2,6-difluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone

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