5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione

Base Information

• Chemical Name: 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione
• CAS No.: 199114-10-8
• Molecular Formula: C₁₉H₁₆F₃N₃O₄S
• Molecular Weight: 439.415

Synonyms:5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione

Chemical Property of 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione

Chemical Property:

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Technology Process of 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione

There total 3 articles about 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

thiazoline-2,4-dione (2295-31-0) + 4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde (199114-59-5) → 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione (199114-10-8)

Guidance literature:

With piperidine; benzoic acid; In toluene; Heating;

DOI:10.1016/S0968-0896(02)00107-4

Reference yield:

4-(2-bromoethyloxy)benzaldehyde (52191-15-8) → 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione (199114-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 31 percent / NaH; LiBr / dimethylformamide / 16 h / 80 °C

2: 31 percent / PhCO₂H; piperidine / toluene / Heating

With piperidine; sodium hydride; benzoic acid; lithium bromide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0968-0896(02)00107-4

Reference yield:

2-ethyl-6-trifluoromethyl-3H-pyrimidin-4-one → 5-[4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]phenylmethylene]thiazolidine-2,4-dione (199114-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 31 percent / NaH; LiBr / dimethylformamide / 16 h / 80 °C

2: 31 percent / PhCO₂H; piperidine / toluene / Heating

With piperidine; sodium hydride; benzoic acid; lithium bromide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0968-0896(02)00107-4

upstream raw materials:

thiazoline-2,4-dione

4-[2-[2-ethyl-4-trifluoromethyl-6-oxo-1,6-dihydropyrimidin-1-yl]ethoxy]benzaldehyde

4-(2-bromoethyloxy)benzaldehyde

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