N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

Base Information

Chemical Name:N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide
CAS No.:221301-30-0
Molecular Formula:C₃₀H₂₆ClF₃N₂O₆S
Molecular Weight:635.06
Hs Code.:

<i>N</i>-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-<i>C</i>,<i>C</i>,<i>C</i>-trifluoro-methanesulfonamide

Synonyms:N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

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Chemical Property of N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

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Technology Process of N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

There total 4 articles about N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-benzyloxy-3-(2-methoxy-5-nitrobenzylidene)-2,2-dimethylchroman-4-one

: 221301-30-0
N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / Pd/C / ethyl acetate; methanol / 1551.44 Torr / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF

3: TEA / CH₂Cl₂ / 0 °C

4: 5 N aq. NaOH / methanol / Ambient temperature

With sodium hydroxide; TEA; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(98)00654-4

Reference yield:

: C₃₁H₂₅ClF₆N₂O₈S₂

: 221301-30-0
N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: With sodium hydroxide; In methanol; Yield given; Ambient temperature;
DOI:10.1016/S0960-894X(98)00654-4

Reference yield:

: 158103-31-2
3-(5-Amino-2-methoxybenzyl)-6-hydroxy-2,2-dimethylchroman-4-one

: 221301-30-0
N-{3-[6-(7-chloro-quinolin-2-ylmethoxy)-2,2-dimethyl-4-oxo-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF

2: TEA / CH₂Cl₂ / 0 °C

3: 5 N aq. NaOH / methanol / Ambient temperature

With sodium hydroxide; TEA; sodium hydride; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00654-4