N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Base Information

• Chemical Name: N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite
• CAS No.: 91887-18-2
• Molecular Formula: C₆₈H₆₂N₇O₁₆P
• Molecular Weight: 1264.25

Synonyms:N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

Chemical Property of N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

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Technology Process of N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite

There total 3 articles about N⁴-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N⁴-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C49H50N5O11P (125190-05-8,125190-08-1) + N-benzoyl-2'-deoxycytidine 3'-benzoate (51549-49-6) → N4-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N4-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite (91887-18-2)

Guidance literature:

Reference yield:

Chloro-<2-(p-nitrophenyl)ethyl>morpholinophosphine (91876-63-0) → N4-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N4-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite (91887-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.25 h

2: 64 percent / tetrazole / acetonitrile / 0.25 h / Ambient temperature

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1055/s-1989-27299

Reference yield:

2-(4-nitrophenyl)ethyl phosphorodichloridite (76101-32-1) → N4-Benzoyl-5'-O-dimethoxytrityl-2'-deoxycytidylyl-(3'-5')-N4-benzoyldeoxycytidylyl O-<2-(p-nitrophenyl)ethyl> phosphite (91887-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: -20 deg C, 1 h, then r.t., 2 h

2: 95 percent / EtN(i-Pr)2 / CH₂Cl₂ / 0.25 h

3: 64 percent / tetrazole / acetonitrile / 0.25 h / Ambient temperature

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1055/s-1989-27299

upstream raw materials:

C₄₉H₅₀N₅O₁₁P

N-benzoyl-2'-deoxycytidine 3'-benzoate

Chloro-<2-(p-nitrophenyl)ethyl>morpholinophosphine

2-(4-nitrophenyl)ethyl phosphorodichloridite

Downstream raw materials:

C₆₈H₆₂N₇O₁₆PS

C₆₈H₆₂N₇O₁₇P

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