C₂₀H₃₁N₂O₆P*ClH

Base Information

Chemical Name:C₂₀H₃₁N₂O₆P*ClH
CAS No.:1416404-33-5
Molecular Formula:C₂₀H₃₁N₂O₆P*ClH
Molecular Weight:462.911
Hs Code.:

C<sub>20</sub>H<sub>31</sub>N<sub>2</sub>O<sub>6</sub>P*ClH

Synonyms:C₂₀H₃₁N₂O₆P*ClH

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Chemical Property of C₂₀H₃₁N₂O₆P*ClH

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Technology Process of C₂₀H₃₁N₂O₆P*ClH

There total 21 articles about C₂₀H₃₁N₂O₆P*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: benzyl [(2S,5S,6S,7R,8R,10aS)-8-[[bis(benzyloxy)phosphoryl]oxy]-6-hydroxy-5-(4-methoxybenzyl)octahydro-1H-7,10a-methanopyrrolo[1,2-a]azocin-2-yl](methyl)carbamate

: 1416404-33-5
C₂₀H₃₁N₂O₆P*ClH

Guidance literature:: benzyl [(2S,5S,6S,7R,8R,10aS)-8-[[bis(benzyloxy)phosphoryl]oxy]-6-hydroxy-5-(4-methoxybenzyl)octahydro-1H-7,10a-methanopyrrolo[1,2-a]azocin-2-yl](methyl)carbamate; With hydrogenchloride; In methanol; water;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; under 760.051 Torr;
DOI:10.1021/jo302362b

Reference yield:

: 1395687-54-3
(R)-1-allyl-5-(benzyloxy)piperidin-2-one

: 1416404-33-5
C₂₀H₃₁N₂O₆P*ClH

Guidance literature:: Multi-step reaction with 19 steps

1.1: trifluoromethylsulfonic anhydride; 2,6-di-tert-butyl-4-methylpyridine / dichloromethane

2.1: lithium naphthalenide / tetrahydrofuran / 1 h / -40 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

4.1: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 - 50 °C

4.3: CSA / 0.17 h / 90 °C

5.1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 °C

8.1: titanium(IV) isopropylate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 12 h / 85 °C

9.1: hydrogenchloride / acetone / 3 h / Reflux

10.1: potassium hexamethylsilazane / tetrahydrofuran / -50 °C

10.2: 0 °C

11.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 760.05 Torr

12.1: samarium diiodide; N,N,N,N,N,N-hexamethylphosphoric triamide / methanol / 12 h / -78 °C

13.1: triethylamine / dichloromethane / 3 h / 20 °C

14.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

15.1: palladium 10% on activated carbon; hydrogen / 760.05 Torr

16.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C

17.1: sodium carbonate / dichloromethane; water / 1 h / 20 °C

18.1: 1H-tetrazole / dichloromethane / 1 h / 0 °C

18.2: -78 - -10 °C

19.1: hydrogenchloride / methanol; water

19.2: 6 h / 20 °C / 760.05 Torr

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1H-tetrazole; titanium(IV) isopropylate; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methylpyridine; samarium diiodide; oxalyl dichloride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jo302362b

Reference yield:

: 1395687-70-3
(3R,6R)-6-[2-(1,3-dioxolan-2-yl)ethyl]-1-allyl-6-vinylpiperidin-3-ol

: 1416404-33-5
C₂₀H₃₁N₂O₆P*ClH

Guidance literature:: Multi-step reaction with 17 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.1: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 - 50 °C

2.3: CSA / 0.17 h / 90 °C

3.1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

6.1: titanium(IV) isopropylate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 12 h / 85 °C

7.1: hydrogenchloride / acetone / 3 h / Reflux

8.1: potassium hexamethylsilazane / tetrahydrofuran / -50 °C

8.2: 0 °C

9.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C / 760.05 Torr

10.1: samarium diiodide; N,N,N,N,N,N-hexamethylphosphoric triamide / methanol / 12 h / -78 °C

11.1: triethylamine / dichloromethane / 3 h / 20 °C

12.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

13.1: palladium 10% on activated carbon; hydrogen / 760.05 Torr

14.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C

15.1: sodium carbonate / dichloromethane; water / 1 h / 20 °C

16.1: 1H-tetrazole / dichloromethane / 1 h / 0 °C

16.2: -78 - -10 °C

17.1: hydrogenchloride / methanol; water

17.2: 6 h / 20 °C / 760.05 Torr

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 1H-tetrazole; titanium(IV) isopropylate; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; samarium diiodide; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; sodium carbonate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation;
DOI:10.1021/jo302362b