4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Base Information

Chemical Name:4-Chloro-2-ethoxycarbonyl-3,5-Lutidine
CAS No.:187222-17-9
Molecular Formula:C₁₀H₁₂ClNO₂
Molecular Weight:213.664
Hs Code.:

Synonyms:4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Suppliers and Price of 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4-Chloro-3,5-dimethylpicolinate
1g
$ 1320.00

Total 2 raw suppliers

Chemical Property of 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Chemical Property:

Boiling Point:313.4±37.0 °C(Predicted)
Density:1.176±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Ethyl4-Chloro-3,5-dimethylpicolinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Ethyl 4-Chloro-3,5-dimethylpicolinate s an intermediate in the synthesis of Omeprazole (O635000), which binds covalently to proton pum, inhibits gastric secreation and is used as an antiulcerative.

Technology Process of 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

There total 7 articles about 4-Chloro-2-ethoxycarbonyl-3,5-Lutidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 187222-16-8
2-Ethoxycarbonyl-3,5-dimethyl-4(1H)-pyridone

: 187222-17-9
4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Guidance literature:: With trichlorophosphate; at 120 ℃; for 1h;
DOI:10.3987/COM-96-7617

Reference yield: 35.0%

: ferrous(II) sulfate heptahydrate

: iron(II) sulfate

: 143798-73-6
4-chloro-3,5-dimethylpyridine

: 187222-17-9
4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Guidance literature:: With sulfuric acid; dihydrogen peroxide; In 2-oxo-propionic acid ethyl ester; DI-water; toluene;

Reference yield:

: 50421-81-3
1-hydroxy-2-methyl-1-penten-3-one

: 187222-17-9
4-Chloro-2-ethoxycarbonyl-3,5-Lutidine

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / anh. potassium carbonate / acetone / 34 h / Heating

2: 20 percent / sodium ethoxide / ethanol / 0.5 h / Heating

3: 92 percent / sulfuric acid / 4 h / Heating

4: 70 percent / p-toluenesulfonic acid monohydrate / toluene / 9 h / Heating

5: 81 percent / hydrogen / 10percent Pd/C / acetic acid / 12 h / 2844.3 Torr / Ambient temperature

6: 88 percent / phosphoryl chloride / 1 h / 120 °C

With sulfuric acid; hydrogen; sodium ethanolate; potassium carbonate; toluene-4-sulfonic acid; trichlorophosphate; palladium on activated charcoal; In ethanol; acetic acid; acetone; toluene;
DOI:10.3987/COM-96-7617