(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

Base Information

Chemical Name:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide
CAS No.:1092477-75-2
Molecular Formula:C₂₂H₂₂F₆N₆O
Molecular Weight:500.447
Hs Code.:

Synonyms:(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

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Chemical Property of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

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Technology Process of (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

There total 4 articles about (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 886-35-1
3,5-bis(trifluoromethyl)phenylhydrazine

: 1092477-74-1
(+/-)-ethyl imidazo[1,2-a]pyridin-6-yl(4-methylpiperazinyl)acetate

: 1092477-75-2
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

Guidance literature:: (+/-)-ethyl imidazo[1,2-a]pyridin-6-yl(4-methylpiperazinyl)acetate; With methanol; potassium hydroxide; water; at 20 ℃; for 48h;

3,5-bis(trifluoromethyl)phenylhydrazine; With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1092477-75-2
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C

1.2: 19 h / 20 °C

2.1: methanol; potassium hydroxide; water / 48 h / 20 °C

2.2: 16 h / 20 °C

With methanol; potassium hydroxide; water; methanesulfonyl chloride; triethylamine; In dichloromethane;

Reference yield:

: 1092477-73-0
(+/-)-ethyl hydroxy(imidazo[1,2-a]pyridin-6-yl)acetate

: 1092477-75-2
(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-imidazo[1,2-a]pyridin-6-yl-2-(4-methylpiperazin-1-yl)acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C

1.2: 19 h / 20 °C

2.1: methanol; potassium hydroxide; water / 48 h / 20 °C

2.2: 16 h / 20 °C

With methanol; potassium hydroxide; water; methanesulfonyl chloride; triethylamine; In dichloromethane;