Multi-step reaction with 8 steps
1: 79 percent / pyridine / 1.) RT, overnight, 2.) 100 deg C, 4 h
2: 83 percent / diphenyl carbonate, sodium bicarbonate / dimethylformamide / 1 h / 150 °C
3: 51 percent / 4-(dimethylamino)pyridine / acetonitrile / 22 h / Ambient temperature
4: 88 percent / 2,2'-azobis(2-methylpropionitrile) (AIBN), n-Bu3SnH / toluene / 6 h / 110 - 120 °C
5: 85 percent / 1N NaOH / aq. ethanol / 2 h / Ambient temperature
6: 78 percent / pyridine / 18 h / 4 °C
7: 75 percent / 4-chlorophenyl phosphorodichloridate / pyridine / 48 h / Ambient temperature
8: 79 percent / NH4OH / dioxane / 3 h / Ambient temperature
With
pyridine; bis(phenyl) carbonate; dmap; ammonium hydroxide; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; 4-chlorophenylphosphorodichloridate;
In
1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00106a034