{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

Base Information

Chemical Name:{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid
CAS No.:1175094-50-4
Molecular Formula:C₂₄H₁₇NO₇
Molecular Weight:431.401
Hs Code.:

Synonyms:{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

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Chemical Property of {[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

Chemical Property:

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Technology Process of {[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

There total 5 articles about {[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1175095-08-5
4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carboxylic acid methyl ester

: 6000-44-8
sodium glycinate

: 1175094-50-4
{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

Guidance literature:: 4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carboxylic acid methyl ester; sodium glycinate; In 2-methoxy-ethanol; for 18h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 1666-28-0
4-bromosalicylic acid

: 1175094-50-4
{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 1 h / 100 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 4 - 20 °C

2.2: 2 h / Cooling

2.3: 2 h / Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Reflux

4.1: 2-methoxy-ethanol / 18 h / Reflux

With sulfuric acid; sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 2-methoxy-ethanol; water;

Reference yield:

: 51067-38-0
4-phenoxyphenylboronic acid

: 1175094-50-4
{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Reflux

2: 2-methoxy-ethanol / 18 h / Reflux

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; 2-methoxy-ethanol; water;