2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one
CAS No.:1321615-75-1
Molecular Formula:C₂₂H₂₀ClN₃O₂S
Molecular Weight:425.939
Hs Code.:

Synonyms:2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

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Chemical Property of 2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

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Technology Process of 2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

There total 6 articles about 2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.9%

: 1321615-70-6
C₁₄H₁₅N₃OS

: 1321615-75-1
2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

Guidance literature:: C₁₄H₁₅N₃OS; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

(4-chlorophenyl)carbonylmethyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 10h;
DOI:10.1016/j.bmc.2011.05.024

Reference yield:

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 1321615-75-1
2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / toluene / 24 h / 90 °C

2.1: sodium hydroxide / water / 15 h

3.1: acetonitrile / 0.5 h / 20 °C

4.1: potassium hydroxide / ethanol / 20 °C / pH 7 - 8

4.2: 2 h / 20 °C

4.3: 20 °C / Reflux

5.1: sodium methylate / methanol / Inert atmosphere; Reflux

5.2: pH 4

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C

6.2: 10 h / 20 °C

With sodium methylate; potassium carbonate; potassium hydroxide; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.05.024

Reference yield:

: 1321615-67-1
ethyl 4-(3,4-dihydroquinolin-1(2H)-yl)-3-oxobutanoate

: 1321615-75-1
2-(4-chlorophenylcarbonylmethylthio)-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / Inert atmosphere; Reflux

1.2: pH 4

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 10 h / 20 °C

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.024