4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide
• CAS No.: 109774-82-5
• Molecular Formula: C₁₅H₂₃NO₄S
• Molecular Weight: 313.418
• Mol file: 109774-82-5.mol

Synonyms:4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

Chemical Property of 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

There total 3 articles about 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-dihydro-2H-pyran (110-87-2) + 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol (13379-98-1) → 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide (109774-82-5)

Guidance literature:

With toluene-4-sulfonic acid; In diethyl ether; for 3h;

DOI:10.1021/ja00323a030

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide (109774-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: 95 percent / p-TsOH*H₂O / diethyl ether / 3 h

With toluene-4-sulfonic acid; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/ja00323a030

Reference yield:

toluene-4-sulfonic acid (104-15-4) → 4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide (109774-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 5 h / Ambient temperature

In dichloromethane;

DOI:10.1016/S0040-4039(00)85349-6

upstream raw materials:

3,4-dihydro-2H-pyran

3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

p-toluenesulfonyl chloride

toluene-4-sulfonic acid

Downstream raw materials:

N-<4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl>-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

C₅₄H₇₅N₃O₁₂S₃

C₆₉H₇₈N₆O₁₂S₆

C₃₉H₅₁N₃O₉S₃