methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

Base Information

Chemical Name:methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate
CAS No.:1419603-38-5
Molecular Formula:C₂₁H₂₇N₃O₄Si
Molecular Weight:413.549
Hs Code.:

Synonyms:methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

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Chemical Property of methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

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Technology Process of methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

There total 5 articles about methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1419603-32-9
5-bromo-N-phenylpyrimidine-2-carboxamide

: 1419603-38-5
methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

1.2: 2 h / -5 - 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium hydride; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1419603-38-5
methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / benzene / 2 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

3.2: 2 h / -5 - 20 °C

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium acetate; sodium hydride; sodium carbonate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;

Reference yield:

: 1419603-34-1
5-bromo-N-phenyl-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

: 1419603-38-5
methyl 2-(2-(phenyl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)pyrimidin-5-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; In 1,4-dioxane; toluene;