N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide
CAS No.:1268832-87-6
Molecular Formula:C₃₁H₄₄NO₃PSSi
Molecular Weight:569.821
Hs Code.:

Synonyms:N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

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Chemical Property of N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

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Technology Process of N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

There total 4 articles about N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1268832-86-5
N-((2S,3R)-1-(diphenylphosphino)-3-hydroxybutan-2-yl)-4-methylbenzenesulfonamide

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 1268832-87-6
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol103145g

Reference yield:

: 1268832-84-3
(R)-2-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-1-tosylaziridine

: 1268832-87-6
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ol103145g

Reference yield:

: 220306-97-8
N-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxymethyl-propyl]-4-methyl-benzenesulfonamide

: 1268832-87-6
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol103145g