N-benzyl-N-chlorocyclohexanamine

Base Information

• Chemical Name: N-benzyl-N-chlorocyclohexanamine
• CAS No.: 1268381-07-2
• Molecular Formula: C₁₃H₁₈ClN
• Molecular Weight: 223.746
• Mol file: 1268381-07-2.mol

Synonyms:N-benzyl-N-chlorocyclohexanamine

Chemical Property of N-benzyl-N-chlorocyclohexanamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyl-N-chlorocyclohexanamine

There total 1 articles about N-benzyl-N-chlorocyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-benzylcyclohexylamine (4383-25-9) → N-benzyl-N-chlorocyclohexanamine (1268381-07-2)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at -10 - 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.11.142

Reference yield: 85.0%

N-benzyl-N-chlorocyclohexanamine (1268381-07-2) + allylmagnesium bromide (1730-25-2) → N-(1-phenylbut-3-en-1-yl)cyclohexanamine (144661-28-9)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; In tetrahydrofuran; diethyl ether; at -50 - 20 ℃; for 3.5h; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tetlet.2010.11.142

Reference yield:

N-benzyl-N-chlorocyclohexanamine (1268381-07-2) + 2-butenylmagnesium bromide (6088-87-5,53247-17-9) → syn-N-(2-methyl-1-phenylbut-3-en-1-yl)cyclohexanamine + anti-N-(2-methyl-1-phenylbut-3-en-1-yl)cyclohexanamine

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium tert-butylate; In tetrahydrofuran; at -50 - 20 ℃; optical yield given as %de; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tetlet.2010.11.142

upstream raw materials:

N-benzylcyclohexylamine

Downstream raw materials:

N-(1-phenylbut-3-en-1-yl)cyclohexanamine