(1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate

Base Information

• Chemical Name: (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate
• CAS No.: 238428-12-1
• Molecular Formula: C₂₀H₂₀N₂O₂
• Molecular Weight: 320.391
• Mol file: 238428-12-1.mol

Synonyms:(1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate

Chemical Property of (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate

There total 4 articles about (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methyl-benzaldehyde (104-87-0) + (S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) → (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate (238428-12-1)

Guidance literature:

With sodium carbonate; In methanol;

DOI:10.1016/S0968-0896(99)00050-4

Reference yield: 59.0%

4-methyl-benzaldehyde (104-87-0) + (S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) → (1R,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate (782478-94-8) + (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate (238428-12-1)

Guidance literature:

4-methyl-benzaldehyde; (S)-tryptophan methyl ester hydrochloride; In methanol; water; at 25 ℃;

With sodium carbonate; In methanol; water;

DOI:10.1021/ci3003655

Reference yield:

4-methyl-benzaldehyde (104-87-0) + L-tryptophan methyl ester (4299-70-1) → (1R,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate (782478-94-8) + (1S,3S)-methyl 1-(4-methylphenyl)-2,3,4,9-tetrahydo-1H-pyrido[3,4-b]indole-3-carboxylate (238428-12-1)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2006.12.112

upstream raw materials:

4-methyl-benzaldehyde

(S)-tryptophan methyl ester hydrochloride

L-tryptophan methyl ester

L-Tryptophan

Downstream raw materials:

C₃₀H₂₄BrN₃O₄

C₃₀H₂₅N₃O₄

methyl 1-( p-tolyl)-9H-pyrido[3,4-b]indole-3-carboxylate