Technology Process of 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-(2-hydroxypropyl)acetamide
There total 10 articles about 2-(12-[[4-(dimethylamino)cyclohexyl]amino]-7-thia-9,11-diazatricyclo[6.4.0.0[2,6]]dodeca-1(8),2(6),9,11-tetraen-3-yl)-N-(2-hydroxypropyl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen fluoride;
In
water; acetonitrile;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: diethylamine; sulfur / ethanol / 20 °C
2.1: 5 h / 180 °C / Inert atmosphere
2.2: Cooling with ice
3.1: trichlorophosphate / 1 h / 110 °C / Inert atmosphere
4.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 55 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5.2: 2 h
6.1: thionyl chloride / 20 °C
7.1: dimethyl sulfoxide / 5 h / 70 °C
8.1: thionyl chloride / Cooling with ice
8.2: 16 h / 70 °C
9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 15 h / 20 °C
9.2: pH 5
10.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
11.1: water; hydrogen fluoride / acetonitrile / 20 °C
With
lithium aluminium tetrahydride; thionyl chloride; hydrogen fluoride; water; potassium carbonate; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 55 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.2: 2 h
3.1: thionyl chloride / 20 °C
4.1: dimethyl sulfoxide / 5 h / 70 °C
5.1: thionyl chloride / Cooling with ice
5.2: 16 h / 70 °C
6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 15 h / 20 °C
6.2: pH 5
7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
8.1: water; hydrogen fluoride / acetonitrile / 20 °C
With
lithium aluminium tetrahydride; thionyl chloride; hydrogen fluoride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
