(+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine

Base Information

• Chemical Name: (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine
• CAS No.: 137655-96-0
• Molecular Formula: C₁₇H₂₀N₆O₂
• Molecular Weight: 340.385
• Mol file: 137655-96-0.mol

Synonyms:(+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine

Chemical Property of (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine

There total 4 articles about (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-96-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / pyridine

2: 38 percent / NaN₃ / dimethylformamide / 12 h / 60 °C

3: Na, EtOH / 80 °C

4: Heating

With pyridine; sodium azide; ethanol; sodium; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570280529

Reference yield:

solketal tosylate (23737-51-1,7305-59-1) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / NaN₃ / dimethylformamide / 12 h / 60 °C

2: Na, EtOH / 80 °C

3: Heating

With sodium azide; ethanol; sodium; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570280529

Reference yield:

4-(azidomethyl)-2,2?dimethyl-1,3-dioxolane (25261-56-7) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Na, EtOH / 80 °C

2: Heating

With ethanol; sodium;

DOI:10.1002/jhet.5570280529

upstream raw materials:

para-methylbenzonitrile

4-(azidomethyl)-2,2?dimethyl-1,3-dioxolane

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

solketal tosylate

Downstream raw materials:

(+/-)-3-2',3'-dihydroxypropyl-5-p-tolyl-7-amino-3H-1,2,3-triazolo<4,5-d>pyrimidine