(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

Base Information

Chemical Name:(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane
CAS No.:111349-79-2
Molecular Formula:C₂₉H₄₇BrO₂Si₂
Molecular Weight:563.766
Hs Code.:

Synonyms:(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

Suppliers and Price of (3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

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Technology Process of (3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

There total 7 articles about (3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 135006-34-7
(3R,4R)-(+)-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexan-1-ol

: 111349-79-2
(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In diethyl ether; for 6h; Ambient temperature;

Reference yield:

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 111349-79-2
(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) H₂O₂, NaOH / 1.) THF, -78 deg C, 5 h

2: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) BH₃-THF, 2.) H₂O₂, NaOH

4: Ph₃P, CBr₄ / diethyl ether / 6 h / Ambient temperature

With sodium hydroxide; borane-THF; carbon tetrabromide; dihydrogen peroxide; triethylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00258a063

Reference yield:

: 135006-32-5
4-tert-butyldiphenylsilyloxy-1-butene

: 111349-79-2
(3R,4R)-(+)-1-bromo-3-methyl-4-<(tert-butyldimethylsilyl)oxy>-6-<(tert-butyldiphenylsilyl)oxy>hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) O₃; 2.) DMS / 1.) CH₂Cl₂-CH₃OH, -78 deg C, 2.) -78 deg C to room temp., 6 h

2: 2.) H₂O₂, NaOH / 1.) THF, -78 deg C, 5 h

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) BH₃-THF, 2.) H₂O₂, NaOH

5: Ph₃P, CBr₄ / diethyl ether / 6 h / Ambient temperature

With sodium hydroxide; borane-THF; 2,3-dimercapto-succinic acid; carbon tetrabromide; dihydrogen peroxide; ozone; triethylamine; triphenylphosphine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00258a063