1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Base Information

• Chemical Name: 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide
• CAS No.: 69221-11-0
• Molecular Formula: C₂₁H₂₄ClN₃O₄
• Molecular Weight: 417.892

Synonyms:1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Chemical Property of 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

There total 3 articles about 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride (69082-74-2) → 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69221-11-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / H₂ / PtO₂ / ethanol / 6 h / 70 °C / 15514.4 Torr

2: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

3: K₂CO₃ / dimethylformamide / 16 h

With sulfuric acid; hydrogen; nitric acid; potassium carbonate; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00366a017

Reference yield:

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide (69082-73-1) → 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69221-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

2: K₂CO₃ / dimethylformamide / 16 h

With sulfuric acid; nitric acid; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00366a017

Reference yield:

N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide (69082-75-3) + 4-Methylbenzyl chloride (104-82-5) → 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide (69221-11-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jm00366a017

upstream raw materials:

N-(5-chloro-2-methoxy-4-nitrophenyl)-4-piperidinecarboxamide

4-Methylbenzyl chloride

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride

Downstream raw materials:

1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (4-amino-5-chloro-2-methoxy-phenyl)-amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 69221-11-0 1-(4-Methyl-benzyl)-piperidine-4-carboxylic acid (5-chloro-2-methoxy-4-nitro-phenyl)-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send