6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

Base Information

• Chemical Name: 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine
• CAS No.: 161923-50-8
• Molecular Formula: C16H17 Cl N4 O8
• Molecular Weight: 428.786
• Mol file: 161923-50-8.mol

Synonyms:6-Chloro-1,9-dihydro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2H-purin-2-one

Chemical Property of 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

Chemical Property:

• PSA: 151.96000
• LogP: 0.50920
• Solubility.: Dichloromethane, Ether, Ethyl acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-hydroxy-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-2-hydroxy-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 161923-50-8) is a compound useful in organic synthesis.

Technology Process of 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

There total 2 articles about 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (16321-99-6) → 6-chloro-2-hydroxy-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl) purine (161923-50-8)

Guidance literature:

With tert.-butylnitrite; water; isopropyl alcohol; at 15 - 20 ℃; Product distribution / selectivity;

Reference yield: 84.0%

2',3',5'-tri-O-acetyl-β-xanthosine (61444-45-9) → 6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2,3-dihydropurin-2-one (161923-50-8)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In dichloromethane; for 3h; Heating;

Reference yield: 95.0%

1-chloro-2,4-dinitro-benzene (97-00-7) + 6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2,3-dihydropurin-2-one (161923-50-8) → 3-N-(2,4-dinitrophenyl)-6-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2,3-dihydropurin-2-one

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

DOI:10.1080/07328319708002532

upstream raw materials:

2',3',5'-tri-O-acetyl-β-xanthosine

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

Downstream raw materials:

isoguanosine

6-chloro-2-(3''-(5''-fluoro-1''-(p-toluenesulfonyl)indolyl)ethyloxy)-3',4',5'-triacetyladenosine

2-(3''-(5''-bromo-1''-(p-toluenesulfonyl)indolyl)ethyloxy)-6-chloro-3',4',5'-triacetyladenosine

6-chloro-2-(3''-(5''-methoxy-2''-methyl-1''-(p-toluenesulfonyl)indolyl)ethyloxy)-3',4',5'-triacetyladenosine