Technology Process of (1R,5S,7aR)-7a-methyl-2,3,5,6,7,7a-hexahydrospiro[indene-1,2'-oxiran]-5-yl 2-(phenylthio)acetate
There total 8 articles about (1R,5S,7aR)-7a-methyl-2,3,5,6,7,7a-hexahydrospiro[indene-1,2'-oxiran]-5-yl 2-(phenylthio)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; toluene;
at 0 ℃;
for 0.666667h;
Inert atmosphere;
DOI:10.1021/jo201153h
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
2: diisobutylaluminium hydride / hexane; dichloromethane / 0.67 h / -78 °C / Inert atmosphere
3: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
5: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0.67 h / 0 °C / Inert atmosphere
With
1H-imidazole; dmap; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
5: Mitsunobu reaction;
DOI:10.1021/jo201153h
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 2 h / -78 °C / Inert atmosphere
2: diisobutylaluminium hydride / diethyl ether; hexane / -78 - -40 °C / Inert atmosphere
3: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
4: diisobutylaluminium hydride / hexane; dichloromethane / 0.67 h / -78 °C / Inert atmosphere
5: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 50 °C / Inert atmosphere
7: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0.67 h / 0 °C / Inert atmosphere
With
1H-imidazole; dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
7: Mitsunobu reaction;
DOI:10.1021/jo201153h
