(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

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Chemical Name:(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate
CAS No.:1269815-54-4
Molecular Formula:C₃₃H₄₅ClN₄O₆
Molecular Weight:629.197
Hs Code.:

(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

Synonyms:(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

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Chemical Property of (R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

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Technology Process of (R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

There total 5 articles about (R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 659731-48-3
5-chloro-2-fluoro-4-iodopyridine

: 1269815-54-4
(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 40 h / 40 °C

3.1: ammonia / water; dimethyl sulfoxide / 20 h / 110 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

4.2: 18 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; ammonia; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 1269815-48-6
[3-(2-amino-5-chloro-pyridin-4-yl)-phenyl]-(tetrahydro-pyran-4-ylmethyl)-carbamic acid tert-butyl ester

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1269815-54-4
(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: (R)-1-Boc-nipecotic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 - 20 ℃; for 0.5h;

[3-(2-amino-5-chloro-pyridin-4-yl)-phenyl]-(tetrahydro-pyran-4-ylmethyl)-carbamic acid tert-butyl ester; With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 380430-68-2
3-(tert-butoxycarbonylamino)phenylboronic acid

: 1269815-54-4
(R)-1-(tert-butyl-3-(4-(3-(tert-butoxycarbonyl)((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylcarbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.2: 40 h / 40 °C

3.1: ammonia / water; dimethyl sulfoxide / 20 h / 110 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

4.2: 18 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; ammonia; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;