-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester

Base Information

• Chemical Name: -benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester
• CAS No.: 134557-99-6
• Molecular Formula: C₃₄H₄₁N₃O₅
• Molecular Weight: 571.717

Synonyms:-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester

Chemical Property of -benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of -benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester

There total 1 articles about -benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane (130406-40-5) + methyl (S)-β-aminobenzenebutanoate trifluoroacetate → -benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester (134557-99-6)

Guidance literature:

With dmap; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 72 h;

DOI:10.1016/0223-5234(93)90078-S

Reference yield: 92.0%

-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester (134557-99-6) → PD 135666 (134557-41-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 25h;

DOI:10.1016/0223-5234(93)90078-S

Reference yield:

-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester (134557-99-6) → -N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-4-phenylbutyl>glycine

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / aq. LiOH / tetrahydrofuran / 25 h / 0 - 20 °C

2: 1.) 1-hydroxybenzotriazole hydrate (HOBt), N,N'-dicyclohexylcarbodimide (DCC), 2.) 4-dimethylaminopyridine, Et₃N / 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 72 h

3: 73 percent / aq. NaOH / ethanol / 5.5 h / 0 - 20 °C

With dmap; lithium hydroxide; sodium hydroxide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;

DOI:10.1016/0223-5234(93)90078-S

upstream raw materials:

N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane

Downstream raw materials:

PD 135666

-glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester

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