3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

Base Information

Chemical Name:3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide
CAS No.:1367177-59-0
Molecular Formula:C₆₅H₁₀₀N₄O₇S₂
Molecular Weight:1113.66
Hs Code.:

Synonyms:3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

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Chemical Property of 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

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Technology Process of 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

There total 6 articles about 3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1219923-22-4
3α-aminoacetoxy-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

: 77778-94-0
4-(N,N-diphenylamino)-4-oxobutanoic acid

: 1367177-59-0
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

Guidance literature:: 4-(N,N-diphenylamino)-4-oxobutanoic acid; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3α-aminoacetoxy-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h;
DOI:10.1002/hc.21002

Reference yield:

: 860298-01-7
12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-3α-hydroxy-N,N-dioctyl-5β-cholan-24-amide

: 1367177-59-0
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: calcium hydride; tetrabutylammomium bromide / toluene / 2 h / 90 °C

2.1: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C

3.1: acetic acid; zinc / 24 h / 20 °C

4.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 48 h / 0 - 20 °C

With sodium azide; calcium hydride; tetrabutylammomium bromide; benzotriazol-1-ol; acetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hc.21002

Reference yield:

: 1219923-20-2
3α-chloroacetoxy-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

: 1367177-59-0
3α-[[[[4-(diphenylamino)-1,4-dioxobutyl]amino]acetyl]oxy]-12α-[[[[(diethylamino)thioxomethyl]thio]acetyl]oxy]-N,N-dioctyl-5β-cholan-24-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C

2.1: acetic acid; zinc / 24 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

3.3: 48 h / 0 - 20 °C

With sodium azide; benzotriazol-1-ol; acetic acid; zinc; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hc.21002