Technology Process of tert-butyl 5-(bis(trimethylsilyl)methyl)-2-(2-(ethoxycarbonyl)allyl)benzoate
There total 3 articles about tert-butyl 5-(bis(trimethylsilyl)methyl)-2-(2-(ethoxycarbonyl)allyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 3-(bis(trimethylsilyl)methyl)benzoate;
With
bis(2,2,6,6-tetramethylpiperidinyl)magnesium lithium chloride;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
With
zinc(II) chloride;
In
tetrahydrofuran;
at -40 ℃;
for 0.25h;
Schlenk technique;
Inert atmosphere;
ethyl 2-bromomethyl-2-propenoate;
With
copper(I) cyanide di(lithium chloride);
In
tetrahydrofuran;
at -40 - 25 ℃;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/chem.201402531
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere
1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere
2.1: bis(2,2,6,6-tetramethylpiperidinyl)magnesium lithium chloride / tetrahydrofuran / 2 h / 25 °C / Schlenk technique; Inert atmosphere
2.2: 0.25 h / -40 °C / Schlenk technique; Inert atmosphere
2.3: -40 - 25 °C / Schlenk technique; Inert atmosphere
With
chloro-trimethyl-silane; bis(2,2,6,6-tetramethylpiperidinyl)magnesium lithium chloride; magnesium; lithium chloride;
In
tetrahydrofuran; ethylene dibromide;
1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere
1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere
2.1: bis(2,2,6,6-tetramethylpiperidinyl)magnesium lithium chloride / tetrahydrofuran / 2 h / 25 °C / Schlenk technique; Inert atmosphere
2.2: 0.25 h / -40 °C / Schlenk technique; Inert atmosphere
2.3: -40 - 25 °C / Schlenk technique; Inert atmosphere
With
chloro-trimethyl-silane; bis(2,2,6,6-tetramethylpiperidinyl)magnesium lithium chloride; magnesium; lithium chloride;
In
tetrahydrofuran; ethylene dibromide;
1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531
